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Multiple Sclerosis

Accurately visualize lesion and brain volume changes over time in multiple sclerosis

icobrain ms

icobrain ms is designed to support the detection and tracking of disease progression, and the evaluation of treatment effectiveness. 


It provides a quantitative analysis of the inflammatory component of the disease, assessing longitudinal changes in FLAIR and T1 lesions. Additionally, icobrain ms can be used to assess changes in brain volume over time, which can be compared to age- and sex-matched healthy individuals. 

icobrain ms+

icobrain ms+ (only available for research) can be used to evaluate the central vein sign and paramagnetic rim lesions based on susceptibility-weighted imaging, and additional brain volumes, and cross-sectional surface area of the C2-C3 section of the cervical spinal cord from T1-w images.


The icometrix multiple sclerosis care management platform

Image by Lino C.

What we often miss in following MS patients is subtle changes that take place over the course of many years. If you are not ordering icobrain for your MS patients, you may be leaving important information on the table.

What we often miss in following MS patients is subtle changes that take place over the course of many years. If you are not ordering icobrain for your MS patients, you may be leaving important information on the table.

Tiron Pechet, Radiologist at Shields Healthcare Group

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150%

Increased detection of disease activity in MS
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2.5x

Faster detection of treatment failure
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68%

outcome improvement when employing icobrain® vs drugs alone
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Image by Lino C.

With icobrain, we can provide a technologic level of observation that previously has only been available for centers in clinical trials. Now, every patient can be measured this way, can be assessed, and we are using this data to make important changes in our day-to-day patient management.

With icobrain, we can provide a technologic level of observation that previously has only been available for centers in clinical trials. Now, every patient can be measured this way, can be assessed, and we are using this data to make important changes in our day-to-day patient management.

Stanley Cohan, Neurologist at Providence

Key scientific publications

Whole brain and grey matter volume of Japanese patients with multiple sclerosis

Akaishi et al. (2017)

Number of MRI T1-hypointensity corrected by T2/FLAIR lesion volume indicates clinical severity in patients with multiple sclerosis

Akaishi et al. (2020)

Comparing longitudinal brain atrophy measurement techniques in a real-world multiple sclerosis clinical practice cohort: towards clinical integration?

Beadnall et al. (2019)

Single MRI-Based Volumetric Assessment in Clinical Practice Is Associated With MS-Related Disability

D'hooghe et al. (2019)

Cost-Effectiveness Analysis of AI-Assisted Radiological Assessment in Patients With Relapsing Remitting Multiple Sclerosis in the UK

Esposito et al. (2022)

Intercontinental validation of brain volume measurements using MSmetrix

Finkelsztejn et al. (2017)

Correlation of clinical findings and brain volume data in multiple sclerosis

Fragoso et al. (2017)

Brain volume loss in Japanese patients with multiple sclerosis is present in the early to middle stage of the disease

Fujimori & Nakashima (2024)

Patterns of cortical grey matter thickness reduction in multiple sclerosis

Fujimori et al. (2021)

The association between MRI brain volumes and computerized cognitive scores of people with multiple sclerosis.

Golan et al. (2020)

Long-term effectiveness of natalizumab on MRI outcomes and no evidence of disease activity in relapsing-remitting multiple sclerosis patients treated in a Czech Republic real-world setting: A longitudinal, retrospective study

Horakova et al. (2020)

Automatic segmentation and volumetry of multiple sclerosis brain lesions from MR images

Jain et al. (2015)

Two Time Point MS Lesion Segmentation in Brain MRI: An Expectation-Maximization Framework, Frontiers in Neuroscience: Brain Imaging Methods

Jain et al. (2016)

Patient-reported outcome measurements in a selective cohort of relapsing–remitting multiple sclerosis patients: relationships with physical disability, cognitive impairment, and MRI-derived metrics

London et al. (2023)

icobrain ms 5.1: Combining Unsupervised and Supervised Approaches for Improving the Detection of Multiple Sclerosis Lesions.

Rakic et al. (2021)

Health Economic Impact of Software-Assisted Brain MRI on Therapeutic Decision-Making and Outcomes of Relapsing-Remitting Multiple Sclerosis Patients—A Microsimulation Study

Sima et al. (2021)

A deep learning model for brain segmentation across pediatric and adult populations

Simarro et al. (2024)

Brain volume loss in multiple sclerosis is independent of disease activity and might be prevented by early disease-modifying therapy

Slezáková et al. (2023)

Reliable measurements of brain atrophy in individual patientswith multiple sclerosis

Smeets et al. (2016)

Automated MRI volumetry as a diagnostic tool for Alzheimer's disease: validation of icobrain dm

Struyfs et al. (2020)

Associations between neurofilament light chain levels, disease activity and brain atrophy in progressive multiple sclerosis

Szilasiova et al. (2022)

A Novel Digital Care Management Platform to Monitor Clinical and Subclinical Disease Activity in Multiple Sclerosis

Van Hecke et al. (2021)

Automated brain volumetrics in multiple sclerosis: a step closer to clinical application

Wang et al. (2016)

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Make every clinical decision with confidence

Latest news & press

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American College of Radiology (ACR) and icometrix collaborate to improve the quality of care for people with Alzheimer’s diseas

Virginia, VA – April 2nd, 2025 The American College of Radiology (ACR), the professional medical society dedicated to advancing radiology...

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Market approval for icobrain aria

icometrix is proud to announce the market approval of icobrain aria , the first market-approved solution for monitoring amyloid-related...

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Groundbreaking clinical validation of icobrain aria

In a landmark achievement for Alzheimer's disease treatment, icometrix unveils the groundbreaking clinical validation of icobrain aria ...

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